Project Summary: Coukos

Project Title: Targeting glioblastoma through tumor endothelial marker-1 (TEM-1)

George Coukos, MD, PhD

• Improved imaging and alternate therapies for GBM are direly needed.
• Investigators will develop a new generation of molecular agents for PET imaging based on targeting TEM-1, a cell-surface molecule present specifically on the GBM vasculature.
• Successful development of this vascular-specific PET imaging tool will markedly aid in the clinical diagnosis of primary or recurrent GBM and may address current limitations in brain imaging for monitoring response to treatment.